Publications

2023

Diwan A. Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy? J Clin Invest. 2023 Jul 17;133(14):e171965. doi: 10.1172/JCI171965. PMID: 37463442

Zhang X, Evans TD, Chen S, Sergin I, Stitham J, Jeong SJ, Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B. Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling. Circ Res. 2023 Jul 21;133(3):200-219. doi: 10.1161/CIRCRESAHA.122.321542. PMID:37350264.

2022

72. Dhindsa S, Champion C, Deol, E, Lui M, Campbell R, Newman J, Yeggalam A, Nadella S, Ahir V, Shrestha E, Kannampallil T, Diwan A. Association of male hypogonadism with risk for hospitalization from COVID-19. JAMA Netw Open. 2022 Sep 1;5(9):e2229747. doi: 10.1001/jamanetworkopen.2022.29747.PMID: 36053534

71. Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela-Ripoll C, Billia P, Diwan A, Javaheri A, Kirshenbaum, LA. Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. Circulation 2022 Aug 19;101161CIRCULATIONAHA121058411. PMID: 35983756

70. Zhang X, Misra SK, Rodriguez-Velez A, Jeong S-J, Yeh Y-S, Fan D, Diwan A, Lodhi I, Pan D, Razani B. Use of Acidic Nanoparticles to Rescue Macrophage Lysosomal Dysfunction in Atherosclerosis. Autophagy 2022 Aug 18;1-18. doi: 10.1080/15548627.2022.2108252. PMID: 35982578

69. Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J Ramos-Pittol JM, Kepp O, Höfler G, Rainer PP, Scherr D, von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S. Fine-tuning cardiac IGF1 receptor signaling to promote healthspan and longevity in male mice. Circulation. 2022 May 26;101161CIRCULATIONAHA122059863. doi: 10.1161/CIRCULATIONAHA.122.059863 PMID: 35616058

68. Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer’s disease. Yan P, Kim KW, Xiao Q, Ma X, Czerniewski LR, Liu H, Rawnsley DR, Yan Y, Randolph GJ, Epelman S, Lee JM, Diwan A. J Clin Invest. 2022 May 5:e152565. doi: 10.1172/JCI152565. Epub ahead of print.

67. TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis. Ma, X., Rawnsley, D. R., Kovacs, A., Islam, et al. JACC: Basic to Translational Science.

66. Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function. Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Martí-Pàmies Í, Mia S, Latimer M, Diwan A, Zhao J, Hauck AK, Krusen B, Nguyen HCB, Blobel GA, Kelly DP, Pei L, Baur JA, Young ME, Lazar MA. Nat Cardiovasc Res. 2022 Jan;1(1):45-58. doi: 10.1038/s44161-021-00001-9.

2021

65. High-fat diet prevents the development of autoimmune diabetes in NOD mice. Clark AL, Yan Z, Chen SX, Shi V, Kulkarni DH, Diwan A, Remedi MS. Diabetes Obes Metab. 2021 Nov;23(11):2455-2465. doi: 10.1111/dom.14486. PMID: 34212475

64. Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19. Dhindsa S, Zhang N, McPhaul MJ, et al. JAMA Netw Open. 2021;4(5):e2111398. doi:10.1001/jamanetworkopen.2021.11398

63. More Energy to Relax: Targeting Epigenetic Effects of Acute Renal Injury to Prevent HFpEF. Diwan A. JACC Basic Transl Sci. 2021 Feb 2 2;6(2):134-136. doi: 10.1016/j.jacbts.2020.12.016. eCollection 2021 Feb. PMID: 33688853

62. Impact of obesity on day-night differences in cardiac metabolism. Mia S, Sonkar R, Williams L, Latimer MN, Frayne Robillard I, Diwan A, Frank SJ, Des Rosiers C, Young ME.FASEB J. 2021 Mar;35(3):e21298. doi: 10.1096/fj.202001706RR.PMID: 33660366

61. Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response. Jeong SJ, Stitham J, Evans TD, Zhang X, Rodriguez-Velez A, Yeh YS, Tao J, Takabatake K, Epelman S, J Lodhi I, D Schilling J, J Debosch B, Diwan A, Razani B.Autophagy. 2021 Mar 11:1-13. doi: 10.1080/15548627.2021.1896906. Online ahead of print.PMID: 337066712

2020

60. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S.Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32105-32113. doi: 10.1073/pnas.2012197117. Epub 2020 Nov 25.PMID: 33239446

59. Sensing Protein Quality in Cardiac Myocytes: p62 Triggers a Lysosomal Response. Diwan A, Gottlieb RA. Circulation Research. 2020;127:519–521. 30 Jul 2020. https://doi.org/10.1161/CIRCRESAHA.120.317567.

58. Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. Rawnsley DR, Diwan A. EBioMedicine. 2020;56:102824. doi:10.1016/j.ebiom.2020.102824

57. Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis. Islam M, Diwan A, Mani K. Front Physiol. 2020;11:586. Published 2020 Jun 4. doi:10.3389/fphys.2020.00586

56. The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models. Bécot A, Pardossi-Piquard R, Bourgeois A, et al. Cells. 2020;9(5):1204. Published 2020 May 12. doi:10.3390/cells9051204

55. High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Zhang X, Sergin I, Evans TD, Jeong SJ, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B. Nat Metab. 2020 Jan;2(1):110-125.

2019

54. TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy. Javaheri A, Bajpai G, Picataggi A, Mani S, Foroughi L, Evie H, Kovacs A, Weinheimer CJ, Hyrc K, Xiao Q, Ballabio A, Lee JM, Matkovich SJ, Razani B, Schilling JD, Lavine KJ, Diwan A. JCI Insight. 2019 Nov 1;4(21).

53. NO to Lysosomes: A Signal for Insulin Resistance in Obesity. Javaheri A, Diwan A. Cell Mol Gastroenterol Hepatol. 2019 May 15. pii: S2352-345X(19)30045-1.

52. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, Liu H, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A. PLoS Biol. 2019 May 14;17(5):e3000245.

51. Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response. Kumar S, Egan BM, Kocsisova Z, Schneider DL, Murphy JT, Diwan A, Kornfeld K. Dev Cell. 2019 Apr 8;49(1):100-117.e6.

50. A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance. Ferey JLA, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1202-H1210.

49. Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. Ma X, Mani K, Liu H, Kovacs A, Murphy JT, Foroughi L, French BA, Weinheimer CJ, Kraja A, Benjamin IJ, Hill JA, Javaheri A, Diwan A. J Am Heart Assoc. 2019 Feb 19;8(4):e010866.

2018

48. Drugging the Hippo (Pathway): A Strategy to Stimulate Cardiac Regeneration? Mani K, Diwan A. JACC Basic Transl Sci. 2018 Nov 12;3(5):654-656.

47. Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor Is the Undercover Boss. Mani K, Javaheri A, Diwan A. Compr Physiol. 2018 Sep 14;8(4):1639-1667.

2017

46. Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Hartupee J, Szalai GD, Wang W, Ma X, Diwan A, Mann DL. Circ Heart Fail. 2017 Dec;10(12). pii: e004252.

45. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A. Autophagy. 2017;13(11):1952-1968.

44. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B. Nat Commun. 2017 Jun 7;8:15750.

2016

43. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. He L, Weber KJ, Diwan A, Schilling JD. J Leukoc Biol. 2016 Nov;100(5):1113-1124.

42. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Cell Metab. 2016 Jul 12;24(1):158-66.

41. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ et al., Autophagy. 2016;12(1):1-222.

2015

40. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Tripoli DL, Czerniewski L, Ballabio A, Cirrito JR, Diwan A, Lee JM. J Neurosci. 2015 Sep 2;35(35):12137-51.

39. IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Kanekura K, Ma X, Murphy JT, Zhu LJ, Diwan A, Urano F. Sci Signal. 2015 Jun 23;8(382):ra62.

38. Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A. Autophagy. 2015;11(9):1537-60.

37. Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress. Ma X, Liu H, Murphy JT, Foyil SR, Godar RJ, Abuirqeba H, Weinheimer CJ, Barger PM, Diwan A. Mol Cell Biol. 2015 Mar;35(6):956-76.

36. Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy. Yang KC, Ma X, Liu H, Murphy J, Barger PM, Mann DL, Diwan A. Circ Heart Fail. 2015 Jan;8(1):175-87.

2014

35. Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae. Emanuel R, Sergin I, Bhattacharya S, Turner J, Epelman S, Settembre C, Diwan A, Ballabio A, Razani B. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1942-1952.

34. Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis. Xiao Q, Yan P, Ma X, Liu H, Perez R, Zhu A, Gonzales E, Burchett JM, Schuler DR, Cirrito JR, Diwan A, Lee JM. J Neurosci. 2014 Jul 16;34(29):9607-20.

2013

33. Ca(2+) leak in atrial fibrillation: junctophilin-2 stabilizes ryanodine receptor. Hill JA, Diwan A. J Am Coll Cardiol. 2013 Nov 19;62(21):2020-2022.

32. Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart. Divakaran VG, Evans S, Topkara VK, Diwan A, Burchfield J, Gao F, Dong J, Tzeng HP, Sivasubramanian N, Barger PM, Mann DL. Circ Heart Fail. 2013 May;6(3):535-43.

31. TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway. Schilling JD, Machkovech HM, He L, Diwan A, Schaffer JE. J Immunol. 2013 Feb 1;190(3):1285-96.

2012

30. Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT et al., Autophagy. 2012 Apr;8(4):445-544.

29. Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Ma X, Godar RJ, Liu H, Diwan A. Autophagy. 2012 Mar;8(3):297-309.

2011

28. Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription. Zhang Y, Matkovich SJ, Duan X, Diwan A, Kang MY, Dorn GW 2nd. J Biol Chem. 2011 Jul 29;286(30):26943-51.

2010

27. Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription. Zhang Y, Matkovich SJ, Duan X, Diwan A, Kang MY, Dorn GW 2nd. J Biol Chem. 2011 Jul 29;286(30):26943-51.

26. Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.Chen Y, Lewis W, Diwan A, Cheng EH, Matkovich SJ, Dorn GW 2nd. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9035-42.

25. MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Matkovich SJ, Wang W, Tu Y, Eschenbacher WH, Dorn LE, Condorelli G, Diwan A, Nerbonne JM, Dorn GW 2nd. Circ Res. 2010 Jan 8;106(1):166-75.

2009

24. Clinical and genetic modifiers of long-term survival in heart failure. Cresci S, Kelly RJ, Cappola TP, Diwan A, Dries D, Kardia SL, Dorn GW 2nd. J Am Coll Cardiol. 2009 Jul 28;54(5):432-44.

23. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support.Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW 2nd. Circulation. 2009 Mar 10;119(9):1263-71.

22. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW 2nd. J Clin Invest. 2009 Jan;119(1):203-12.

2008

20. Lack of pathologic Q waves: a specific marker of viability in myocardial hibernation. Jeon HK, Shah GA, Diwan A, Cwajg JM, Park TH, McCulloch ML, Zoghbi WA. Clin Cardiol. 2008 Aug;31(8):372-7.

19. Targeting erythroblast-specific apoptosis in experimental anemia. Diwan A, Koesters AG, Capella D, Geiger H, Kalfa TA, Dorn GW 2nd. Apoptosis. 2008 Aug;13(8):1022-30.

18. The rationale for cardiomyocyte resuscitation in myocardial salvage. Dorn GW 2nd, Diwan A. J Mol Med (Berl). 2008 Oct;86(10):1085-95.

17. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW 2nd. Nat Med. 2008 May;14(5):510-7.

16. Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn GW 2nd. Circulation. 2008 Jan 22;117(3):396-404.

2007

15. Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. Diwan A, Krenz M, Syed FM, Wansapura J, Ren X, Koesters AG, Li H, Kirshenbaum LA, Hahn HS, Robbins J, Jones WK, Dorn GW. J Clin Invest. 2007 Oct;117(10):2825-33.

14. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW 2nd. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6794-9.

13. Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Galvez AS, Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J, Lynch RA, Marreez Y, Dorn GW 2nd. Circ Res. 2007 Apr 13;100(7):1071-8.

12. Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Diwan A, Dorn GW 2nd. Physiology (Bethesda). 2007 Feb;22:56-64.

11. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW 2nd, Wang HS, Valdivia HH, Chu G, Kranias EG. Circulation. 2007 Jan 23;115(3):300-9.

2006

10. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW 2nd. Circ Res. 2006 Oct 27;99(9):996-1003.

2005

9. Murine echocardiography: a practical approach for phenotyping genetically manipulated and surgically modeled mice. Syed F, Diwan A, Hahn HS. J Am Soc Echocardiogr. 2005 Sep;18(9):982-90.

8. Doppler estimation of left ventricular filling pressures in patients with mitral valve disease. Diwan A, McCulloch M, Lawrie GM, Reardon MJ, Nagueh SF. Circulation. 2005 Jun 21;111(24):3281-9. Epub 2005 Jun 13. Erratum in: Circulation. 2005 Jul 26;112(4):e76.

2004

7. Duality of innate stress responses in cardiac injury, repair, and remodeling. Wilson EM, Diwan A, Spinale FG, Mann DL. J Mol Cell Cardiol. 2004 Oct;37(4):801-11.

6. Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. Diwan A, Dibbs Z, Nemoto S, DeFreitas G, Carabello BA, Sivasubramanian N, Wilson EM, Spinale FG, Mann DL. Circulation. 2004 Jan 20;109(2):262-8.

2003

5. Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype. Dibbs ZI, Diwan A, Nemoto S, DeFreitas G, Abdellatif M, Carabello BA, Spinale FG, Feuerstein G, Sivasubramanian N, Mann DL. Circulation. 2003 Aug 26;108(8):1002-8.

4. Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Flesch M, Höper A, Dell’Italia L, Evans K, Bond R, Peshock R, Diwan A, Brinsa TA, Wei CC, Sivasubramanian N, Spinale FG, Mann DL. Circulation. 2003 Aug 5;108(5):598-604.

3. Inflammatory mediators and the failing heart: a translational approach. Diwan A, Tran T, Misra A, Mann DL. Curr Mol Med. 2003 Mar;3(2):161-82.

2002

2. Asymptomatic left ventricular dysfunction: an overlooked part of the continuum of heart failure. Misra A, Diwan A, Mann DL, Deswal A. Heart Fail Monit. 2002;3(2):42-8.

1. Regulation of cardiac fibroblast cellular function by leukemia inhibitory factor.Wang F, Trial J, Diwan A, Gao F, Birdsall H, Entman M, Hornsby P, Sivasubramaniam N, Mann D. J Mol Cell Cardiol. 2002 Oct;34(10):1309-16.